Hydroxyurea and Sickle Cell Disease
Hydroxyurea is a medicine that can help children and adults with sickle cell disease. Research studies show that hydroxyurea lowers the following:
- The numbers of acute chest syndrome (pneumonia) events
- The number of pain crises
- The need for blood transfusions
- The number of trips to the hospital
Hydroxyurea for the Treatment of Sickle Cell Disease
The long-term efficacy and toxicity of hydroxyurea for infants are undefined, and its role in preventing organ dysfunction is unknown. Short-term feasibility of hydroxyurea administration, toxicities, hematologic effects, and effect on spleen function in infants with sickle cell anemia (SCA) were reported (Hydroxyurea Safety and Organ Toxicity [HUSOFT] trial).
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